Sébastien Jauliac is a principal investigator in the Department of Cancer at INSERM in the UMR7212 CNRS / U944 INSERM at the Institute of Hematology, Hospital saint-Louis, University Paris Diderot, in Paris.

Our team works on the molecular mechanisms involved in breast cancer metastases formation. We study the role of NFAT transcription factors in the regulation of the migratory and invasive capacities of breast carcinoma, contributing to the formation of metastases. We currently work on both the identification of the mechanisms of NFAT transcription factors activation and the identification of their downstream genes required to increase or blunt the cellular motility. The goals of these studies is to be able to provide new therapeutic targets to prevent or cure breast cancer metastases.

Our discovery of the expression and function of the NFAT transcription factors in breast cancer (Jauliac et al. 2002, Fougère et al. 2010) has allowed for the first time to highlight the key role of these transcription factors in breast cancer biology and other cancers types. Our studies have opened a new field of research in the study of cancers.

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No positions availables at the present time.