THE JAULIAC LABORATORY: NFAT AND CANCER

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Positions availables

- We are seeking for a highly motivated Master 2 student to work on NFAT and breast cancer

If you are interested please contact Dr Sébastien Jauliac at sebastien.jauliac@inserm.fr



 
Welcome to the Jauliac lab home page

Sébastien Jauliac is a principal investigator in the Department of Cancer at INSERM in the Skin Research Center UMR-S 976 at the Institute of Hematology, Hospital saint-Louis, University Paris Diderot, in Paris.

Our team works on the molecular mechanisms involved in breast cancer metastases formation. We study the role of NFAT transcription factors in the regulation of the migratory and invasive capacities of breast carcinoma, contributing to the formation of metastases. We currently work on both the identification of the mechanisms of NFAT transcription factors activation and the identification of their downstream genes required to increase or blunt the cellular motility. The goals of these studies is to be able to provide new therapeutic targets to prevent or cure breast cancer metastases.

Our discovery of the expression and function of the NFAT transcription factors in breast cancer (Jauliac et al. 2002; Yeoli-Lerner et al., 2005; Fougère et al. 2010) has allowed for the first time to highlight the key role of these transcription factors in breast cancer biology and other cancers types (Bégué et al., 2012). Our team have identified key genes targeted by the NFAT transcription factors to modulate breast cancer carcinoma motility (Fougère et al., 2010; Germann et al., 2012; Gaudineau et al., 2012). Critically we have shown that depending on the NFAT isotype and the cellular context the consequences on genes regulation and cell motility can be completely divergent (Fougère et al., 2010; Gaudineau et al., 2012). Our studies have opened a new field of research in the study of cancers.


 

Recent Lab News

- Lorelei Naudeau defended her PhD Thesis in the B2T program on March 31, 2014.  She obtained her Thesis with the highest mention, congratulations Dr Lorelei and best of Luck for your future projects!

*** Paper Published ***

- Lipocalin 2 (LCN2), the TNF-like receptor TWEAKR and its ligand TWEAK act downstream of NFAT1 to regulate breast cancer cell invasion.
Benoît Gaudineau, Marjorie Fougère, Frédéric Guaddachi, Frédéric Lemoine, Pierre de la Grange and Sébastien Jauliac.
Journal of Cell Science jcs.105023; Advance Online Publication July 5, 2012, doi:10.1242/jcs.105023
Pubmed

*** Paper Published ***
- Inducible expression and pathophysiological functions of T-plastin in cutaneous T-cell lymphoma.
Elodie Bégué, Francette Jean-Louis, Martine Bagot, Sébastien Jauliac, Jean-Michel Cayuela, Liliane Laroche, Nathalie Parquet, Hervé Bachelez, Armand Bensussan, Gilles Courtois and Laurence Michel.
Blood-2011-09-379156; published ahead of print May 24, 2012, doi:10.1182/blood-2011-09-379156



- Lucie Coillard received the first prize for her poster on "Molecular basis of NFAT1 and NFAT3 opposite effects on breast carcinoma invasion" at the 2012 RJS congress in Saint-Louis Hospital. Congratulation Lucie !!

*** Paper Published ***
- Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor.
S Germann, L Gratadou, E Zonta, E Dardenne, B Gaudineau, M Fougère, S Samaan, M Dutertre, S Jauliac and D Auboeuf.
Oncogene. advance online publication, January 23, 2012; doi:10.1038/onc.2011.618.
Lab directions
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